D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain

IP Chessell, AW Procter, PT Francis, DM Bowen - Brain Research, 1991 - Elsevier
IP Chessell, AW Procter, PT Francis, DM Bowen
Brain Research, 1991•Elsevier
The action of d-Cycloserine (DCS) at the strychnine-insensitive glycine recognition site of
the NMDA receptor-ionophore complex has been studied with membranes from inferior
parietal cortex of patients with Alzheimer's disease. The maximal response of the site,
measured using [3 H] MK-801 binding, was 64% of that observed with glycine. Stimulation of
binding induced by DCS in the presence of fixed concentrations of glycine resulted in a
family of dose-response curves, consistent with the antibiotic having the property of a partial …
Abstract
The action of d-Cycloserine (DCS) at the strychnine-insensitive glycine recognition site of the NMDA receptor-ionophore complex has been studied with membranes from inferior parietal cortex of patients with Alzheimer's disease. The maximal response of the site, measured using [3H]MK-801 binding, was 64% of that observed with glycine. Stimulation of binding induced by DCS in the presence of fixed concentrations of glycine resulted in a family of dose-response curves, consistent with the antibiotic having the property of a partial agonist at this glycine site. It is proposed that because of circumscribed glutamatergic pyramidal cell pathology DCS will have benefit for Alzheimer's patients over and above all other types of cognitive impairment.
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